Order Sotalol (Sotalol) tablets online in the USA

| Product Name | Sotalol |
| Dosage | 80 mg, 120 mg, 160 mg, 240 mg |
| Active Ingredient | Sotalol hydrochloride |
| Form | Oral Tablets |
| Description | Prescription antiarrhythmic (Class III) and nonselective beta‑blocker for certain ventricular arrhythmias and for maintaining sinus rhythm in atrial fibrillation/flutter; requires ECG and renal monitoring due to risk of QT prolongation. |
| How to Order Without Prescription | U.S. prescription required; telehealth or provider verification available |
Sotalol is a well‑established prescription medication in the United States used to manage certain serious heart rhythm disorders. It is supplied as oral tablets in multiple strengths, including 80 mg, 120 mg, 160 mg, and 240 mg, allowing clinicians to individualize dosing based on your rhythm, kidney function, and electrocardiogram (ECG) response. Unlike medicines intended for minor conditions, sotalol must be prescribed and managed by a healthcare professional because it can affect the heart’s electrical system.
Several brand and generic versions are marketed in the U.S., such as Betapace, Betapace AF, and Sorine, with pharmacies dispensing FDA‑approved generics widely. For atrial fibrillation or flutter, initial dosing typically requires monitoring in a medical facility due to the risk of QT prolongation and torsades de pointes (a dangerous ventricular arrhythmia). Our pharmacy partner serves patients across the USA and can coordinate prescription verification or connect you with telehealth options when appropriate. Delivery is fast and discreet, and support from licensed pharmacists is available to help you use sotalol safely.
Sotalol price in the USA
In the U.S., sotalol is available as a cost‑effective generic. Actual prices vary by strength, quantity, pharmacy location, and whether you use insurance, a discount card, or a mail‑order service. As a general guide, many retail pharmacies offer generic sotalol at competitive cash prices, and 30 tablets of common strengths are often affordable compared with other antiarrhythmics. Larger fills (60 or 90 tablets) may reduce the per‑tablet cost.
Our partner pharmacy provides transparent pricing and convenient home delivery. If your clinician prescribes sotalol 80 mg twice daily, for example, you may find monthly costs vary depending on your benefits, coupons, and local options. Always compare prices and consider 90‑day supplies if appropriate for chronic therapy. Pharmacists can advise on cost‑saving strategies while ensuring you remain on the prescribed dose.
Because sotalol dosing is adjusted using ECG and kidney function, it’s important not to change strengths or schedules for price reasons without medical guidance. Ask your prescriber if a different fill quantity or pharmacy choice could meet your budget while maintaining your clinical monitoring schedule.
If you obtain medication via mail‑order, factor in shipping time and ensure you reorder in advance to avoid treatment gaps. Our U.S. online service helps schedule timely refills and supports reminders aligned with your dosing plan.
Where can I get Sotalol in the United States?
Sotalol is a prescription‑only medicine in the U.S. To obtain it legally and safely, you’ll need a prescription from a licensed clinician and, for many patients with atrial fibrillation/flutter, an initial period of monitored dosing in a healthcare facility. After your dose is stabilized, refills are typically dispensed through community or mail‑order pharmacies and can be delivered right to your home.
Our U.S.‑serving online pharmacy streamlines the process by coordinating prescription verification and shipment. If you don’t yet have a prescription, we can help connect you to a licensed U.S. provider or cardiology service for evaluation when appropriate. We’ve supported patients nationwide for years with a strong emphasis on safety, timely fulfillment, and pharmacist counseling tailored to heart rhythm management.
This service is especially helpful if you live far from a specialty clinic or prefer secure home delivery. We follow FDA and U.S. regulatory requirements, ensuring that prescriptions are validated and that dispensing complies with state and federal laws. Our customer care team is available to answer questions about insurance use, out‑of‑pocket options, and how to coordinate follow‑up monitoring.
Sotalol in the USA: getting started
Starting sotalol should always be done under medical supervision, especially for atrial fibrillation/flutter. Here’s the typical sequence:
- Clinical evaluation: Your clinician confirms the indication (e.g., maintenance of sinus rhythm in AF/AFL or treatment of certain ventricular arrhythmias) and reviews your medical history, current medications, and prior rhythm treatments.
- Baseline testing: ECG to measure QTc, heart rate, and rhythm; labs to assess electrolytes (potassium, magnesium), kidney function (serum creatinine, creatinine clearance), and, when appropriate, other cardiac workup.
- Initiation and monitoring: Many patients, especially those with AF/AFL, start or reinitiate sotalol in a facility with continuous ECG monitoring for at least 3 days while doses are adjusted.
- Maintenance at home: Once stable, you continue the prescribed regimen at home. Follow‑up ECGs and labs are scheduled to ensure ongoing safety and effectiveness.
- Refills and adherence: Use one pharmacy if possible, set reminders, and avoid missing doses. Contact your care team promptly if you notice concerning symptoms or medication changes.
What is sotalol?
Sotalol is both a Class III antiarrhythmic and a nonselective beta‑adrenergic blocker. As a Class III agent, it blocks potassium channels (primarily IKr), prolonging cardiac repolarization and the action potential duration. This effect can help prevent re‑entry‑based arrhythmias. As a beta‑blocker, sotalol blunts sympathetic stimulation, reduces heart rate, and lowers myocardial oxygen demand, which can stabilize the cardiac rhythm under adrenergic stress.
Clinically, sotalol is used to treat life‑threatening ventricular arrhythmias and to maintain sinus rhythm in patients with symptomatic atrial fibrillation or atrial flutter who have been restored to normal rhythm. It is not indicated for patients with asymptomatic premature beats or trivial arrhythmias. Due to the risk of QT prolongation and torsades de pointes, careful selection, dosing, and monitoring are essential.
Other specialist‑guided uses may include certain supraventricular tachycardias in select patients or pediatric arrhythmias in specialized centers. Such uses should be managed by clinicians experienced in electrophysiology and pediatric cardiology, with individualized risk–benefit evaluation.
Sotalol for atrial fibrillation and atrial flutter
Atrial fibrillation (AF) and atrial flutter (AFL) are common supraventricular tachyarrhythmias originating in the atria. They can cause palpitations, fatigue, shortness of breath, lightheadedness, and decreased exercise tolerance. In many patients, AF/AFL leads to irregular ventricular response and an increased risk of stroke. Management strategies include rate control, rhythm control, stroke prevention, and treatment of underlying conditions such as hypertension, sleep apnea, or structural heart disease.
Rhythm control aims to restore and maintain normal sinus rhythm. After cardioversion or spontaneous conversion, sotalol may be prescribed to help maintain sinus rhythm and reduce symptomatic recurrences. Its dual action—beta‑blockade and potassium channel blockade—can be effective in patients who require both adrenergic dampening and prolongation of atrial refractoriness.
Before starting sotalol for AF/AFL, clinicians assess QTc, electrolytes, and renal function. Initiation typically occurs in a monitored setting for at least 3 days with continuous ECG and serial QT measurements after each dose adjustment. This approach reduces the risk of torsades de pointes by allowing prompt dose modification or discontinuation if the QTc lengthens beyond safe thresholds (commonly ≥500 ms, depending on clinical context). Ongoing evaluation helps determine whether sotalol is the right long‑term rhythm strategy or if alternatives (e.g., dofetilide, amiodarone, flecainide, propafenone, dronedarone, or catheter ablation) might be more appropriate.
Once a maintenance dose is set, periodic follow‑up includes ECG monitoring, renal function tests, and electrolyte checks. If your health status changes—such as developing kidney impairment, starting a new medicine that can prolong QT, or experiencing persistent bradycardia—your healthcare professional may adjust the dose or switch therapies.
In U.S. practice, adherence to the prescribed dosing schedule and routine monitoring are key to minimizing risk and maximizing symptom relief. Do not change your dose or stop taking sotalol without speaking to your prescribing clinician.
Why sotalol is selected for rhythm maintenance
Antiarrhythmic selection balances efficacy with safety and coexisting conditions. Sotalol may be favored when:
- Beta‑blocking benefit is desired alongside Class III antiarrhythmic effects
- There is a need to avoid the extracardiac toxicities associated with some other antiarrhythmics
- Renal function and QTc are appropriate for safe dosing and monitoring is feasible
- The patient has tolerated beta‑blockers previously and lacks severe asthma or bronchospasm
It may be avoided or used cautiously in patients with borderline QTc, electrolyte disturbances, unstable heart failure, significant bradycardia, high‑grade AV block without pacing, or severe renal impairment. Shared decision‑making with your cardiologist ensures you understand expected benefits, alternative options, and monitoring needs.
QT prolongation and torsades de pointes: key safety warning
Sotalol can prolong the QT interval, which increases the risk of torsades de pointes, a potentially life‑threatening ventricular tachycardia. The risk rises with higher doses, reduced kidney function (leading to higher drug exposure), low potassium or magnesium, bradycardia, structural heart disease, and concomitant QT‑prolonging drugs. This is why, in the U.S., initiating or reinitiating sotalol—especially for AF/AFL—typically requires inpatient monitoring for at least 3 days.
Your care team will check QTc after each dose adjustment and ensure potassium (usually ≥4.0 mEq/L) and magnesium are repleted. If the QTc becomes excessive or arrhythmic symptoms occur, the dose is lowered or the medication is stopped. Patients receive education on recognizing symptoms of dangerous rhythm changes, such as sudden dizziness, near‑syncope, fainting, or a racing or irregular heartbeat.
Does sotalol also act as a beta‑blocker?
Yes. In addition to its Class III properties, sotalol is a nonselective beta‑blocker (blocks β1 and β2 receptors). This contributes to heart rate control and suppression of adrenergic‑triggered arrhythmias but may also lead to bradycardia, fatigue, or bronchospasm in susceptible individuals. Patients with reactive airway disease should discuss risks and alternative options with their clinician.
Sotalol for ventricular arrhythmias
Sotalol is indicated for certain life‑threatening ventricular arrhythmias, such as sustained ventricular tachycardia. In this setting, it can reduce arrhythmic episodes and help stabilize rhythm, particularly in patients for whom other treatments are unsuitable or ineffective. Selection depends on individual anatomy, scar burden, ischemic status, device therapy (e.g., implantable cardioverter‑defibrillator), and prior response to antiarrhythmics.
As with AF/AFL, careful monitoring is essential. Initiation in a hospital allows electrophysiology teams to observe rhythm responses and adjust therapy. Some patients may ultimately undergo catheter ablation in addition to or instead of medication to reduce arrhythmia burden.
Initiation and monitoring requirements in the U.S.
U.S. prescribing information emphasizes safety during initiation or reinitiation of sotalol. For many indications—especially AF/AFL—patients are admitted for at least 3 days with continuous ECG monitoring. Doses are titrated based on QTc and renal function, with serial ECGs obtained 2–4 hours after each dose until steady state is approached.
Before discharge, clinicians reinforce home instructions and schedule follow‑up. You may receive a monitoring plan that includes:
- Periodic ECGs to reassess QTc and rhythm
- Routine labs for electrolytes and kidney function
- Review of all current medicines, supplements, and over‑the‑counter products
- Education on warning symptoms and when to call 911
Patients stabilized on a maintenance dose should continue with one dispensing pharmacy if possible and notify their prescriber before starting any new medication that may alter QT interval or interact with sotalol.
Mechanism of action
Sotalol’s electrophysiologic effects stem from two complementary actions:
- Class III antiarrhythmic action: Blocks rapid delayed rectifier potassium current (IKr), prolonging phase 3 repolarization and action potential duration, which can prevent reentrant arrhythmias and extend atrial and ventricular refractoriness.
- Nonselective beta‑blockade: Reduces sympathetic drive to the heart by antagonizing β1 and β2 receptors, lowering heart rate and myocardial oxygen demand and reducing premature beats and adrenergic‑facilitated arrhythmias.
The combination of these mechanisms makes sotalol effective for rhythm stabilization, but it also necessitates stringent monitoring to avoid excessive QT prolongation and bradyarrhythmia.
Safety and tolerability
Millions of patients worldwide have used beta‑blockers and Class III antiarrhythmics under clinical supervision. With sotalol, the most serious risk is torsades de pointes due to QT prolongation, particularly at higher doses or in renal impairment. More common side effects include fatigue, dizziness, bradycardia, and gastrointestinal upset. Because sotalol includes beta‑blocking activity, it can exacerbate bronchospasm in patients with asthma or severe COPD and may mask hypoglycemia symptoms in people with diabetes.
Sotalol is primarily eliminated by the kidneys, so dosing must be adjusted based on creatinine clearance to avoid accumulation. Clinically relevant drug interactions include other agents that prolong the QT interval or that reduce potassium/magnesium levels, which intensify torsades risk. Coordination between your prescriber and pharmacist helps prevent problems by reviewing medication lists at each visit and with every refill.
Adult dosing and titration
Your exact dose will be individualized by your clinician. Common adult regimens include:
- Atrial fibrillation/flutter (maintenance of sinus rhythm): Often initiated at 80 mg twice daily if creatinine clearance (CrCl) is above 60 mL/min, then titrated at 3‑day intervals based on QTc, heart rate, and symptoms. Many patients stabilize between 80–160 mg twice daily; some may require 240 mg/day in divided doses.
- Ventricular arrhythmias: Frequently start at 80 mg twice daily (or 80 mg once daily if limited by renal function), titrating up as needed and tolerated. Maximum doses depend on QTc response and patient‑specific risks.
Do not alter the dose on your own. If you miss a dose, take it as soon as you remember unless it’s close to the next dose; never double up. Consistency matters: take doses at the same times each day. If you experience lightheadedness, fainting, very slow pulse, or new/worsening palpitations, contact your clinician immediately or seek emergency care.
Renal dosing and adjustments
Because sotalol is renally cleared, dosage frequency is adjusted by creatinine clearance to reduce the risk of accumulation and QT prolongation. As a general framework used by many U.S. clinicians:
- CrCl > 60 mL/min: Typically every 12 hours (twice daily)
- CrCl 40–60 mL/min: Often every 24 hours (once daily)
- CrCl 30–40 mL/min: Consider extended intervals with careful ECG monitoring
- CrCl < 30 mL/min: Usually avoid or use extreme caution under specialist supervision
Electrolytes (potassium and magnesium) should be kept in the normal range, with potassium commonly maintained at ≥4.0 mEq/L. The dose will be withheld or reduced if the QTc becomes excessive or if you develop symptomatic bradycardia or other safety concerns.
Contraindications and cautions
Do not use sotalol if you are allergic to it or if any of the following apply unless your clinician specifically advises otherwise:
- Baseline QTc prolongation or congenital long QT syndrome
- Severe bradycardia, sick sinus syndrome, or second/third‑degree AV block without a functioning pacemaker
- Uncompensated heart failure or cardiogenic shock
- Severe asthma or history of bronchospasm from beta‑blockers
- Creatinine clearance too low for safe dosing
- Untreated electrolyte abnormalities, especially hypokalemia or hypomagnesemia
Discuss all health conditions with your provider, including thyroid disease, diabetes, pulmonary disease, prior arrhythmias, and any recent changes in medications. Together, you and your clinician will determine whether sotalol is appropriate or whether an alternative is safer.
Drug interactions and QT‑prolonging combinations
Combining sotalol with other QT‑prolonging drugs or agents that deplete potassium/magnesium increases torsades risk. Your clinician and pharmacist will assess all prescription and over‑the‑counter products to avoid unsafe combinations whenever possible.
Examples of medicines that may interact include certain antiarrhythmics, macrolide and fluoroquinolone antibiotics, azole antifungals, antipsychotics, methadone, and some antidepressants, as well as diuretics that can lower potassium/magnesium. Using other beta‑blockers or non‑dihydropyridine calcium channel blockers (e.g., verapamil, diltiazem) with sotalol may increase bradycardia or AV block risk. Always report new or stopped medicines to your care team.
How to take sotalol correctly
Take sotalol exactly as prescribed, ideally at the same times daily. You can take it with or without food, but be consistent with your choice. Swallow tablets whole with water.
Do not stop sotalol abruptly unless directed by your clinician, as sudden withdrawal can worsen arrhythmias or lead to rebound tachycardia. If your dose is being changed, follow the tapering or titration plan closely, with scheduled ECG and lab checks as recommended.
Pregnancy and breastfeeding
Data on sotalol use in pregnancy are limited. Beta‑blockers may be associated with fetal growth restriction or neonatal effects such as bradycardia or hypoglycemia. If you are pregnant, planning to become pregnant, or breastfeeding, discuss risks and benefits with your cardiologist and obstetric provider. Sotalol is excreted into breast milk; infants should be monitored for signs of beta‑blockade if maternal use is deemed necessary.
Pharmacist’s tips for taking sotalol
Consistency, monitoring, and communication are the pillars of safe sotalol therapy. Keep these points in mind:
- Keep all ECG and lab appointments; call if you can’t make one so it can be rescheduled promptly.
- Maintain adequate hydration and a balanced diet; low potassium or magnesium increases the risk of QT prolongation.
- Report any new dizziness, fainting, slow pulse, or palpitations immediately.
- Carry a current medication list and share it at every healthcare visit.
- Avoid over‑the‑counter stimulants and certain cold medicines that can affect heart rhythm; ask your pharmacist first.
- If you have asthma or COPD, inform your clinician immediately if you notice wheezing or shortness of breath.
Safety Precautions
Never combine sotalol with other QT‑prolonging agents unless specifically directed by your specialist and monitored with ECG. Avoid abrupt discontinuation. Correct low potassium or magnesium before starting and throughout therapy. If you have diabetes, monitor for masked hypoglycemia symptoms. Use caution when driving or operating machinery until you know how sotalol affects you.
Alcohol may exacerbate dizziness or low blood pressure; discuss alcohol use with your clinician. If you are scheduled for surgery or dental work, inform the team that you take sotalol.
Patients with severe asthma, advanced AV block without pacing, or decompensated heart failure generally should not use sotalol unless a specialist determines it is necessary and safe within a monitored setting.
Sotalol side effects
Not everyone experiences side effects, and many are mild and transient. Contact your clinician if any effect is persistent or bothersome.
Common side effects can include:
- Fatigue or low energy
- Dizziness or lightheadedness
- Slow heart rate (bradycardia)
- Shortness of breath, especially in those with reactive airway disease
- Nausea or stomach upset
- Headache or sleep disturbances
Serious side effects require urgent medical attention:
- Fainting, near‑fainting, or sudden severe dizziness
- Very slow pulse, chest pain, or confusion
- Wheezing or bronchospasm in people with asthma/COPD
- Signs of torsades de pointes (sudden palpitations with dizziness or collapse)
Symptoms and signs to watch for
Common, usually transient effects may include:
- Unusual tiredness or weakness
- Mild stomach discomfort, decreased appetite, or nausea
- Drowsiness or lightheadedness
- Mild anxiety or restlessness
- Minor changes in heart rate
- Occasional sleep changes
Signs of excessive beta‑blockade or low blood pressure may include:
- Sweating with dizziness or faintness
- Headache with blurred vision
- Pronounced weakness or cold extremities
- Muscle cramps, especially if electrolytes are low
- Nausea, vomiting, or abdominal discomfort
- Cough, shortness of breath, or chest tightness
- Low blood pressure (feeling faint upon standing)
- Palpitations or irregular heartbeat
- Chills or an overall unwell feeling
- Persistent dizziness
At the start of therapy, you may notice temporary fatigue or lightheadedness. This often improves as your body adjusts, but report symptoms that are severe, sudden, or worsening.
Seek urgent care if you experience any of the following serious effects:
- Fainting or near‑fainting episodes
- New or worsening chest pain
- Severe shortness of breath or wheezing
- Markedly slow heart rate or confusion
- Eye symptoms with visual changes accompanied by dizziness and palpitations
- Swelling of hands, ankles, or feet with breathing difficulty
- Any signs suggestive of a dangerous rhythm (sudden palpitations with dizziness or collapse)
Reporting side effects
If you experience any side effects, contact your clinician or pharmacist promptly. In the U.S., serious side effects can also be reported to the FDA’s MedWatch program. Never ignore symptoms like fainting, severe dizziness, or sudden palpitations—call 911 or seek emergency care.
Sotalol: interactions with other medicines
Tell your healthcare providers about all prescription and over‑the‑counter medicines, vitamins, and herbal supplements. Interactions can increase the risk of serious heart rhythm problems or excessive slowing of the heart.
Medicines that may interact with sotalol include (not a complete list):
- Other antiarrhythmics (e.g., amiodarone, dofetilide, quinidine, procainamide)
- Macrolide and fluoroquinolone antibiotics (e.g., clarithromycin, erythromycin, levofloxacin)
- Azole antifungals (e.g., ketoconazole, itraconazole)
- Antipsychotics and certain antidepressants with QT‑prolonging potential (e.g., haloperidol, ziprasidone)
- Methadone
- Diuretics that can lower potassium or magnesium (e.g., furosemide), raising torsades risk
- Other beta‑blockers or non‑dihydropyridine calcium channel blockers (e.g., verapamil, diltiazem)
- Digoxin (additive effects on heart rate and AV conduction)
- Clonidine (risk of bradycardia; caution with withdrawal)
- Insulin and certain oral hypoglycemics (beta‑blockers may mask hypoglycemia symptoms)
Keep an up‑to‑date list of your medications and bring it to each appointment. Do not start or stop any medicine without consulting your prescriber or pharmacist.
Expert recommendations for U.S. patients
Because sotalol affects the heart’s electrical system, safety comes first. Our clinical team recommends that patients work closely with their cardiology providers, adhere strictly to follow‑up plans, and keep electrolytes and kidney function within target ranges. If you require refills through a home‑delivery pharmacy, set reminders early to prevent missed doses. Our service verifies U.S. prescriptions and offers timely support nationwide so you can focus on your health.
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